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Palmitoylethanolamide (PEA) is a natural substance that has many health benefits. It stops pain and inflammation, protects the heart, and improves brain function.
Palmitoylethanolamideis a substance produced in the body naturally to combat inflammation. It can be found in soybean lecithin, egg yolk, peanut meal and other foods.
In addition, PEA is available as a supplement in tablet, capsule, and powder form to help with chronic and neuropathic pain relief. It is commonly used as a food supplement.
Since its discovery in the 1950’s, it has been widely researched as a pain suppressant and anti-inflammatory. It has found to have little to no known side effects.

Health Benefits of Palmitoylethanolamide

1) PEA Reduces Pain and Inflammation

In humans, PEA reduced the pain intensity in patients given a PEA supplement than those without a PEA supplement .
PEA reduced pain levels in patients with back pain better than in patients not given PEA .
In women with pelvic pain, PEA improved the pain and sexual function symptoms in 6 months .
PEA decreased pain intensities in patients with fibromyalgia syndrome .
In chemotherapy-caused pain, PEA can help treat nerve pain in cancer patients .
In animals, adelmidrol, a PEA equivalent, reduced acute and chronic inflammation .
PEA-treated mice had less inflammation and lung damage than those treated without PEA .
PEA has an anti-inflammatory effect on mice with collagen-induced arthritis .
In mice, PEA helped reduced spinal cord injury-induced inflammation .

2) PEA Protects the Brain

In stroke patients given PEA, recovery outcomes, such as cognitive skills and brain status, improved compared to stroke patients not given PEA .
PEA improved cognitive and social behaviors in autistic children .
In mice, PEA helps preserve brain cells and reduces the expression of pro-inflammatory enzymes. PEA may reduce brain inflammation and brain cell death .
Mice given PEA had improved results in neuron regeneration after spinal cord injury .
In rats, a pre-treatment of PEA reduced seizure duration, indicating PEA may also have anti-epileptic properties .
In mice injected with neurotoxins, PEA reduced some of the neurotoxic and neuroinflammatory effects .

3) PEA Benefits the Heart

In mice with induced heart attacks, PEA reduced heart tissue injury, levels of inflammatory cytokines, and cell death .
Rats treated with PEA for 5 weeks had lower blood pressure than rats not treated with PEA .

4) PEA is Good for Eye Health
In patients with eye diseases, PEA has anti-inflammatory benefits in eye cells and may be used as a treatment supplement, especially for those with glaucoma and diabetic nerve damage .

Additionally, PEA counteracted eye pressure that occurred after eye surgery .
In human patients with normal tension glaucoma, PEA treatment improved the visual field .
In diabetic rats, PEA reduced inflammation in eye cells but preserved the blood-retinal barrier .
Also, PEA reduced inflammation in rats’ eyes and reduced damage .

5) PEA Helps Gut Function

Adelmidrol, a PEA equivalent, is anti-inflammatory and can help manage inflammatory bowel disease
In rats, PEA lowered blood pressure and helped protected against kidney injury .
PEA also normalized intestinal movement in mice with irritable bowel syndrome .


  • Palmitoylethanolamide exerts neuroprotection and reduces inflammatory secondary events associated with brain ischemia-reperfusion injury (middle cerebral artery occlusion (MCAo)) (R).
  • In one pivotal, double-blind, placebo-controlled trial in 636 sciatic pain patients, the number needed to treat to reach 50% pain reduction compared to baseline was 1.5 after 3 weeks of treatment (R).
  • Interestingly, Palmitoylethanolamide also showed protective scavenging effect, through superoxide dismutase induction, and dampened unfolding protein response, interfering with glucose-regulated protein 78 expression and PERK-eIF2α pathway (R).
  • Palmitoylethanolamide treatment reduces myocardial tissue injury, neutrophil infiltration, adhesion molecules (ICAM-1, P-selectin) expression, proinflammatory cytokines (TNF-α, IL-1β) production, nitrotyrosine and PAR formation, nuclear factor kB expression, and apoptosis (Fas-L, Bcl-2) activation (R).

Additional information

Pack Size

60 capsules, Buy 1 get 1 Free

6 reviews for Palmitoylethanolamide

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  1. Jennie (verified owner)

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  2. Joan Adam (verified owner)

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    Excellent service. Would recommend without reservation

  3. Joan Adam (verified owner)

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    Excellent speedy service

  4. Diane (verified owner)

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  5. Joan Adam (verified owner)

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  6. Joan Adam (verified owner)

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    Has help my cavalier enornously

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