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Oral Vitamin B12 as an alternative to injections

  • Vitamin B12 (cobalamin) deficiency is extremely common in cats with EPI, and is seen in more than half of dogs with the condition. Because the body can store up the vitamin under normal conditions, it may take some time before it reaches a critically low point. The reason an animal becomes deficient is that vitamin B12 is not absorbed from the food eaten by animals suffering from EPI.
  • Dogs and cats with EPI may be additionally compromised by decreased production of a substance called intrinsic factor (IF) by the cells of the pancreas. This substance helps the body to absorb the vitamin into the bloodstream. Without sufficient IF, the animal will have even greater difficulty in getting enough vitamin B12. In the cat, the pancreas is the only site of intrinsic factor production. and when the pancreas is compromised, IF deficiency (and thus B12 deficiency) results.
  • Once a deficiency of B12 does occur, the animal will have difficulty gaining (or maintaining) weight, even when he or she may have been doing well on enzyme replacement therapy. The dog or cat will also become lethargic and confused. This is because vitamin B12 plays an important role in intestinal health, as well as brain function.
  • Because of this, any animal that is not improving on enzyme replacement therapy should be checked for B12 deficiency to determine if supplementation is necessary. Low levels of vitamin B12 are sometimes associated with another condition called small intestinal bacterial overgrowth (SIBO). This build-up of bacteria can lead to B12 deficiency in dogs as the organisms bind the vitamin and make it unavailable for absorption by the intestine.

Treating Vitamin B12 Deficiency

  •  Those animals who are not properly treated for B12 deficiency will have a very poor prognosis and will not show improvement when only treated for EPI. Because animals with EPI are unable to absorb certain nutrients and have a diminished capacity to produce intrinsic factor, giving them oral supplementation of B12 doesn’t help. Chemeyes B12 contains intrinsic factor and is a suitable alternative to vitamin injections.

Once an animal has a normal level of B12 in the bloodstream, he or she should begin to gain weight and improve considerably, even in the face of EPI.

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